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اطلاعات دوره: 
  • سال: 

    2018
  • دوره: 

    11
  • شماره: 

    2
  • صفحات: 

    118-124
تعامل: 
  • استنادات: 

    1
  • بازدید: 

    222
  • دانلود: 

    0
چکیده: 

Aim: Pathway Analysis of gastric atrophy to find new molecular prospective of disease. Background: Gastric atrophy as a process which is accompanied with “ loss of glans” in stomach can be considered as a risk factor of gastric cancer. Here, the correlated biochemical Pathways to the disorder have been analyzed via protein-protein interaction (PPI) network Analysis. Methods: The genes related to gastric atrophy were retrieved by STRING database and organized in a network by Cytoscape. Three significant clusters were determined by ClusterONE plug-in of Cytoscape. The elements of cluster-2 which contained all central nodes of the network were enriched by ClueGO and the biochemical Pathways discussed in details. Results: The number of seven central nodes (which are included in cluster-2); INS, TP53, IL6, TNF, SRC, MYC, and IL8 were identified. The biochemical Pathways related to the elements of cluster-2 were determined and clustered in nine groups. The Pathways were discussed in details. Conclusion: Pathway Analysis indicates that the introduced central genes of the network can be considered as biomarkers of gastric atrophy.

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نویسندگان: 

نشریه: 

Dicle Tip Dergisi

اطلاعات دوره: 
  • سال: 

    0
  • دوره: 

    46
  • شماره: 

    1
  • صفحات: 

    27-32
تعامل: 
  • استنادات: 

    1
  • بازدید: 

    153
  • دانلود: 

    0
کلیدواژه: 
چکیده: 

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بازدید 153

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نشریه: 

تاریخ ایران

اطلاعات دوره: 
  • سال: 

    1401
  • دوره: 

    14
  • شماره: 

    2
  • صفحات: 

    115-131
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    191
  • دانلود: 

    198
چکیده: 

شهر بندری ترمذ در تمام دوران حیات خود حلقه اتصال سیاسی اقتصادی خراسان و آسیای مرکزی بوده و از دوران باستان تا معاصر، بر روند تحولات تاریخی این منطقه تاثیر گذاشته است. در این مقاله که به روش توصیفی تحلیلی و با تکیه بر داده های تاریخی و جغرافیایی دست اول گردآوری شده است، ضمن توصیف موقعیت جغرافیایی شهر ترمذ، به بررسی فراز و نشیب های تاریخی این شهر در زمان سلسله های مختلف حاکم بر ایران و خراسان بزرگ (خراسان و آسیای میانه) می پردازیم. بررسی اهمیت اقتصادی و ژیوپولتیکی ترمذ نیز بخشی از اهداف پژوهش حاضر است. نتایج بررسی ها نشان می دهد این گذرگاه تاریخی که امروزه در جنوبی ترین نقطه ازبکستان قرار دارد، بسته به رویکرد سیاسی حاکمان، نقش مهمی در حفظ یا به مخاطره افکندن تمامیت ارضی ایران و نیز رونق یا عدم رونق اقتصادی خراسان بزرگ داشته است. ترمذ در سطح منطقه ای نیز به عنوان پل اقتصادی مهمی در مسیر جاده بزرگ معروف به جاده خراسان، و یا جاده ابریشم، در اتصال ایران به آسیای مرکزی و چین و هند نقش بسزایی داشته است.

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نویسندگان: 

Ramezani Malihe | Biuck Mohsen | Nikunahad Ayob

اطلاعات دوره: 
  • سال: 

    1401
  • دوره: 

    7
  • شماره: 

    2
  • صفحات: 

    23-54
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    144
  • دانلود: 

    7
چکیده: 

Purpose: The flourishing of political parties and currents is one of the signs of the degree of development in societies. In contemporary Iran and since the formation of the constitutional movement, political currents have gone through many ups and downs and it can be said that political currents in Iran after the Islamic Revolution have not yet reached the stage of institutionalization and stability. A characteristic feature of political currents in Iran is the divergence and division among political currents in recent decades, and this can be one of the reasons for the instability and cross-sectional and seasonal activity of political parties in Iran. Therefore, the necessity of leading research seeks to answer the question of how factors and divergence among political currents in Iran after the victory of the Islamic Revolution can be analyzed? And what are the scenarios for the advancement of political currents in Iran?Method: To answer this question, the method of causal-layer Analysis, which is one of the qualitative methods in futures research, has been used.Findings: The research findings indicate that this divergence is due to a wide range of reasons from the level of causal systems (from the institutionalization of power to the formation of parties as elitist initiatives), worldview and discourse (from charismatic political authority to culture). Subsidiary-follower politics to myth-metaphor (Iranian individualism to belief in a strong state-weak society) can be analyzed.Conclusions: Three scenarios for the future of Iranian political currents can be considered: integration of currents as the security valve of the political system, the collapse of political currents in the traditional form, integration and consolidation in new social movements (virtualized parties).

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اطلاعات دوره: 
  • سال: 

    2014
  • دوره: 

    3
  • شماره: 

    SUPPL. (1)
  • صفحات: 

    134-134
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    401
  • دانلود: 

    0
چکیده: 

Glaucoma is a group of multifactorial ocular diseases and the second leading cause of blindness worldwide. Primary open angle (POA) is the most common type of glaucoma, characterized by progressive optic nerve degeneration. Numerous genes and proteins have been revealed to be associated with POAG, but the pathologic mechanisms of the disease are still poorly understood. Proteomics, the collective study of proteins in an organism at a given condition, has extensively been used for the high-throughput identification of proteins related to POAG. A significant obstacle in proteomics studies is the data variability which makes it hard to interpret the results. Pathway Analysis and network topological information can help address the challenge and provide a greater appreciation of the disease mechanism and progression. The purpose of this paper is to determine POAG biological and network information to further understand the mechanisms associated with POAG. PANTHER classification system is used, including classification with gene ontology, protein class and Pathway. 474 gene/protein IDs were extracted from previous proteomic studies. Among Pathways found by PANTHER, apoptosis signaling Pathway was the most significant (with the p-value of 5.54E-12). Other PANTHER categories results demonstrated that developmental processes, receptor binding, extracellular region and extracellular matrix proteins were the most significant biological process, molecular function, cellular component and protein class respectively. A network Analysis on proteins was also performed using STRING database and cytoscape software. The resulted POAG network, containing 312 nodes and 1348 edges was clustered into 9 subnetworks by CytoCluster application.

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اطلاعات دوره: 
  • سال: 

    1400
  • دوره: 

    52
  • شماره: 

    2
  • صفحات: 

    97-108
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    158
  • دانلود: 

    15
چکیده: 

Recognition and understanding the genetic control of traits, combining ability and genetic structure are directly related to the success of breeding programs. For this purpose, a 7 × 7 one-way diallel design was conducted in a randomized complete block design with three replications. The measured traits were included plant height, height to the first capsule, number of days to 50% and 90% of flowering, number of capsules per plant, number of seeds per capsule, number of days to physiological ripening, number of branches, leaves number and length, 1000-seeds weight, capsule weight, length and width, chlorophyll a, b and total chlorophyll, biological andeconomic yields, harvest index, oil and protein percentage. Analysis of variance showed that there was a significant difference between genotypes and diallel Analysis showed that the additive variance of all traits and dominant variance of all traits except height to the first fruit-bearing capsule were significant. The oltan cultivar was the best and Ardestan genotype was the worst genotype in terms of general combining ability. Sabzevar×TS-3 and Sirjan×Fars were the best hybrids in most traits. The general heritability was between 0.90 to 0.96 for biologic yield and number of branches, respectively and narrow heritability was between 0.36 to 0.91 for the number of branches and harvest index, respectively. The Analysis of variance by Hayman method confirmed the results of Griffing Analysis.

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نشریه: 

Galen Medical Journal

اطلاعات دوره: 
  • سال: 

    2020
  • دوره: 

    9
  • شماره: 

    1
  • صفحات: 

    0-0
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    127
  • دانلود: 

    0
چکیده: 

Background: The rate of death due to cardiovascular disease (CVD) is growing. Investigations about CVD that leading to introduce varieties of metabolites is available. The monitoring of these metabolites to find effective ones in the future of clinic applications is the main aim of this study. Materials and Methods: Numbers of 34 metabolites for the CVD are extracted from literature and designated for interaction determinations by MetScape V 3. 1. 3. The compound-reaction-enzyme-gene network was constructed and the Pathways were analyzed. Based on the presence of metabolites in the Pathways the critical compounds were determined. Results: Pathway Analysis revealed 18 disturbed Pathways related to the CVD. glycerophospholipid metabolism Pathway including 27 compounds is related to the 9 queried metabolites. L-Serine which was communed between 5 Pathways and also was presented in the largest Pathway was identified as the critical compound. Conclusion: It can be concluded that L-Serine is a proper biomarker candidate for CVD diagnosis and also patients follow up approaches.

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نویسندگان: 

نشریه: 

MEDICAL ONCOLOGY

اطلاعات دوره: 
  • سال: 

    2024
  • دوره: 

    41
  • شماره: 

    7
  • صفحات: 

    0-0
تعامل: 
  • استنادات: 

    1
  • بازدید: 

    4
  • دانلود: 

    0
کلیدواژه: 
چکیده: 

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بازدید 4

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اطلاعات دوره: 
  • سال: 

    1402
  • دوره: 

    13
  • شماره: 

    4
  • صفحات: 

    61-83
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    43
  • دانلود: 

    9
چکیده: 

As the most complex manufactured structures, cities face excessive population growth. Their expansion has intensified on high-risk sites, and the available evidence also indicates the continuous increase of all types of natural crises in terms of intensity and frequency. Scientific and experimental findings show that the best way to deal with danger is to promote the resilience of settlements in different dimensions (social, economic-livelihood, physical-spatial and institutional); in other words, resilience in both human and environmental dimensions comprehensively. It decreases and increases. This research has evaluated and analyzed the components of resilience in Sari. The method of the present study is applied in terms of purpose and descriptive-analytical and field in nature. The statistical population in this research includes citizens living in the four districts of Sari, and the sample size was determined based on Cochran's formula of 383 people, who were selected from among the statistical population by stratified sampling. The questionnaire is the method of collecting library and field information and its most important tool. For data Analysis, descriptive and inferential statistics (one-sample t-test and structural equation modeling) were used by SPSS and Smart PLS software, and entropy and SAW models were exerted. The research results indicate that the situation of the four regions of Sari regarding social components has better conditions than other dimensions of resilience. In terms of institutional components, they have a vulnerable state. According to the entropy model, among the components of resilience, the institutional dimension has the most weight, and the economic dimension has the least weight. Moreover, according to the SAV model, Region 1 ranks first, and Region 3 of Sari ranks last in having the components of resilience dimensions.

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نویسندگان: 

حیدری ج. | منتصری م.

اطلاعات دوره: 
  • سال: 

    0
  • دوره: 

    -
  • شماره: 

    2
  • صفحات: 

    0-0
تعامل: 
  • استنادات: 

    1
  • بازدید: 

    443
  • دانلود: 

    0
کلیدواژه: 
چکیده: 

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بازدید 443

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